Antinociceptive and anti-inflammatory properties of the hydroalcoholic extract of the Melilotus indicus (L) in male mice

Abdolhossein MIRI, Elahe SHAHRAKI, Kaveh TABRİZİAN
1.558 331

Abstract


Abstract. In current study, the antinociceptive and anti-neuropathic pain effects of hydroalcoholic extract of Melilotus indicus in male mice were assessed using formalin and hot plate tests, respectively. Cotton pellet- induced granuloma model was employed for anti- inflammatory assessments. Melilotus indicus hydroalcoholic extract (50 and 100 mg/kg, oral gavage) reduced the time and the number of lickings during the late phase of the formalin test. Anti-neuropathic pain properties were obtained with the dose of 100 mg/kg. Anti-inflammatory effect of this extract (100 mg/kg) was confirmed by a significant decrease in Cotton pellet weight.


Keywords


Antinociceptive, Melilotus indicus, Neuropathic pain, Formalin test, inflammati

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References


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Figure 1. Effects of melilotus indicus, morphine and diclofenac in the first (A and B) and second phase (C and D) of

the formalin test. Each value represents the mean ± S.E.M. (n=7). **p< 0.01 and ***p<0.001 significantly different

from the control animals.