A Novel Vehicle for Entrapment of Drugs: Doxorubicin-loaded bilayer-surface magnetite nanoparticle

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Abstract. In the past few decades, Magnetite (Fe3O4) nanoparticles have attracted growing research interest that this material has many applications in medicine and drug delivery, Coated magnetic particles, called carriers are very useful for delivering chemotherapeutic drugs. We are herein reporting a synthesis of doxorubicin-loaded bilayer-surface magnetite nanoparticles. The particles were first stabilized with Stearic acid as a primary surfactant, followed by Maleic anhydride-methyl acrylate (MAN-MA) copolymer as a secondary surfactant to form nanoparticles with hydrophobic inner shell and hydrophilic corona. Then anticancer drug doxorubicin (DOX) was selected as a model Drug, That loaded at modified magnetic nanoparticles. The structural, morphological and magnetic properties of as-prepared sample were characterization by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectra, scanning electron microscopy/energy dispersive x-ray analysis (SEM-EDAX) and magnetic measurements were investigated using vibrating sample magnetometer (VSM). The particles were exhibited super paramagnetic behavior at room temperature with saturation magnetization (Ms) about 50 emu/g magnetite. We demonstrate that the drug DOX is attached to the nanoparticles surface, that the binding of DOX to the nanoparticles was confirmed by FT-IR analysis. The present finding show that DOX loaded nanoparticles coated by copolymer are promising for magnetically targeted drug delivery.


Doxorubicin, loaded bilayer, magnetite nanoparticle, novel vehicle, entrapment of drugs

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Kim DK, Mikhaylova M, Wang FH, Keht J, Bjelke B, Zhang Y, et al. Chem Mater 2003:15:4343–51.

Gamarra LF, Brito GES, Pontuschka WM, Amaro E, Parma AHC, Goya GF. J Magn Magn Mater 2005;289:439–41.

Jun YW, Huh YM, Choi JS, Lee JH, Song HT, Kim S, et al. J Am Chem Soc 2005;127:5732–3.

Cheng FY, Su CH, Yang YS, Yeh CS, Tsai CY, Wu CL, et al. Biomaterials 2005;26:729- 38.

Lawaczeck R, Menzel M, Pietsch H. Appl Organomet Chem 2004;18:506–13.

Asmatulu R, Zalich MA, Claus RO, Riffle JS. J Magn Magn Mater 2005;292: 108–19.

Tan ST, Wendorff JH, Pietzonka C, Jia ZH, Wang GQ. Chem Phys Chem 2005;6:1461–5.

Roger J, Pons JN, Massart R, Halbreich A, Bacri JC. Eur Phys J Appl Phys 1999;5:321–5.

Liberti PA, Rao CG, Terstappen LWMM. J Magn Magn Mater 2001;225:301–7.

Sonvico F, Mornet S, Vasseur S, Dubernet C, Jaillard D, Degrouard J, et al. Bioconjugate Chem 2005;16:1181–8.

Kohler N, Sun C, Wang J, Zhang M. Langmuir 2005;21:8858–64.

Zhang JL, Srivastava RS, Misra RDK. Langmuir 2007;23:6342–51.

Zhang Y, Zhang JJ. Colloid Interface Sci 2005;283:352–7.

Hu F, Li Z, Tu C, Gao MJ. Colloid Interface Sci 2007;311:469–74.

Pankhurst QA, Connolly J, Jones SK, Dobson JJ. Phys D Appl Phys 2003;36: 167–81.

Liu G, Yang H, Zhou J, Law SJ, Jiang Q, Yang G. Biomacromolecules 2005;6:1280–8.

Eun HK, Yangkyu A, Hyo SL. J Alloys Compounds 2007;434–435:633–6.

Michael DK, Yumei X, Carol JM, Martha RF, Haitao C, Axel JR. Eur J Pharm Sci 2008;35:96–103.

Xie J, Xu C, Xu Z, Hou Y, Young KL, Wang SX, et al. Chem Mater 2006;18: 5401–3.

Yuan JJ, Armes SP, Takabayashi Y, Prassides K, Leite CAP, Galembeck F, et al. Langmuir 2006;22:10,989–93.

Gomez-Lopera SA, Arias JL, Gallardo V, Delgado AV. Langmuir 2006;22: 2816–21.

Xianqiao L, Kaminski MD, Chen H, Torno M, Taylor L, Rosengart AJ. J Controlled Release 2007;119:52–8.

Si S, Li CL, Wang X, Yu D, Peng Q, Li Y. Cryst Growth Des 2005;5(2):391–3.

Ragheb RT, Riffle JS. Polymer 2008;49:5397–404.