Deneysel periodontitis oluşturulmuş diyabetik sıçanlarda α-tokoferol’ün alveoler kemik kaybı üzerine etkileri

Mükerrem Hatipoglu, Nilgün Özlem Alptekin, Mustafa Cihat AVUNDUK
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Objectives: A variety of clinical and experimental studies investigated the influence of diabetes on the periodontium, as well as the impact of periodontitis on diabetes status. The aim of this study was to investigate the effects of α-tocopherol on alveolar bone loss in rats with experimental periodontitis with/without streptozotocin (STZ)-induced diabetes.Materials and Methods: Forty male Sprague Dawley rats were included in the study and after anesthesia 3/0 silk sutures were placed at the subgingival level of the mandibular right first molars. These animals were divided into two groups: Healty group (Group I) and diabetic group by single injection of 50 mg/kg STZ (Group II). These groups divided into two subgroups; twenty rats were saline group (Group IA, Group IIA) and other twenty rats (Group IB, Group IIB) were α-tocopherol (40mg/kg/day) group. After 3 weeks, all rats were sacrified and the tissues were fixed using neutral buffered 10% formaldehyde solution for histometrical investigation. Alveolar bone loss (ABL), were analyzed by using image analysis program. Statistical comparisons were performed by using one-way analysis of variance with significance set at p<0.05.Results: Data were evaluated after the histometrical examination and there were no statistically significant differences in ABL between the study groups (p>0.05). Conclusions: Analysis of these data demonstrated that α-tocopherol treatment was not affected the ABL of rats with experimental periodontitis with/without STZ-induced diabetes


Diabetesα-tocopherolABL Experimental periodontitisA B S T R A C T

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