Cytotoxicity evaluation of methacrylate- and silorane-based composite resins

Ozden Ozel Bektas, Digdem Eren, Gulsah Goktolga Akin, Zubeyde Akin Polat
2.467 566


Objectives: The objective of this study was to investigate and compare the cytotoxic effects of four composite resin materials with different content.

Material and Methods: Two traditional methacrylate-based (Clearfil AP-X, RefleXions), as well as a self-adhering methacrylate-based (Vertise Flow) and a silorane-based (Filtek Silorane) composite resin were tested in the experiment. Ten cylindrical specimens were made of each material, using a mould (2mm. thick and 8 mm. in diameter). An agar diffusion method was employed, and cytotoxicity rankings were determined using lysis index scores. For statistical analysis, Kruskal-Wallis and Mann-Whitney U-tests were used.

Results: Amongst the composite resins, the silorane-based composite was found to be less cytotoxic than the methacrylate-based composite resins, which all had the same cytotoxicity ranking.

Conclusions: The silorane-based composite resin was considered more biocompatible than the methacrylate-based composite resins.


Cytotoxicity, methacrylate-based composite resin, silorane-based composite resin, self-adhesive composite resin

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