The relationship between ABO blood types and development of cerebral venous sinus thrombosis

Aslı Bolayır, Burhanettin Çiğdem
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Aim: Several studies in the last few decades demonstrated that patients with non-O blood groups (A, B, AB) have increased prothrombic tendency. In addition, many thrombotic disorders have been shown to be closely related to the blood group. However, the role of blood types in cerebral venous sinus thrombosis (CVST) development is unknown.Materials and Methods: Our study included 41 patients who visited the Neurology Department at Cumhuriyet University Hospital and who were diagnosed with CVST between the dates 01/01/2008 and 30/09/ 2016, together with 50 age- and sex-matched controls. The patient and control groups were compared in terms of blood group distribution. In addition, the patient group was divided into two groups according to whether they had parenchymal brain lesions or not, and the effect of the blood group on the prognosis was also assessed.Results: While the blood group distribution in the control group reflected the overall distribution of the Turkish population, the proportion of the non-O blood group in the patient group was higher than in the control group, however the difference between the two groups was not statistically significant. Similarly, there was no statistically significant difference in blood group distribution between patients with and without parenchymal lesions in the patient group. Logistic regression analysis showed that the blood group was not an independent variable in the development of CVST.Conclusion: As a result, the percentage of non-O blood group was higher in patients with CVST than healthy controls; however this is not statistically significant. There is a need for more prospective and extensive future studies on this issue.


Cerebral venous sinus thrombosis; ABO blood group;Prothrombic tendency

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