Relationship between platelet-to-lymphocyte ratio and cardiac syndrome X

Hasan Ata Bolayir
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Cardiac syndrome X consist of anginal-like typical chest pain with positive cardiovascular stres test or presence of ischemia on myocardial perfusion scintigraphy but no flow-limiting stenosis on coronary angiography. The more likely pathophysiologic mechanisms for patients with CSX are subsequent microvascular ischemia, endothelial dysfunction and inflammation which may be the explanation of their anginal-like chest pain. Platelet to lymphocyte ratio is a potential biomarker for inflammation, and associated with endothelial dysfunction. We aimed to compare the role of platelet to lymphocyte ratio in patients with cardiac syndrome X and control subjects in this study.


The study group consist of 100 patients who underwent coronary angiography and were diagnosed as cardiac syndrome X according to the presence of exercise-induced typical angina pectoris and ischemia on myocardial perfusion scintigraphy with angiographically normal coronary arteries. For control subjects, we recruited 100 healthy gender- and age-matched individuals who were seen for health check-ups.


According to comparison of the hematological indices, mean value of the platelet to lymphocyte ratio in study population was higher than control group (260±16 vs 217±14, respectively; p=0.04) whereas the other hematological parameters did not differ between groups significantly.


The platelet to lymphocyte ratio, which is easily calculated from routinely studied compete blood count and therefore requires no additional cost might be usefull for the evaluation of cardiac syndrome X based on the results of our study.

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