Benign ve malign endometriyal patolojilerin klinik ve demografik özelliklerinin karşılaştırılması

Dinçer Sümer, Ayşe Gonca Yenicesu, Abdullah Boztosun, Fırat Çil, Yasin Bıyık, Ahmet Emin Mutlu, Ali Yanık
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Abstract


Aim. The objective of this study is to compare clinical and demographic data of benign and malign pathologies of endometrium and to describe risc factors for endomatrial carcinoma. Method. Eighty-eight patients which was hysterectomised in our clinic between 2006 and 2010 was included. Twenty eight of these has the diagnosis as ‘proliferative endometrium’, twenty nine as ‘hyperplasia of endometrium’, thirty-one as ‘endometrioid type of endometrial carcinoma’. Data were collected from patient files retrospectively. Results. Pregnancy and parity rate, presence of diabetes mellitus and smoking were not altered for groups. Endometrial thickness and presence of hypertension were significantly higher for carcinoma group. Endometrial carcinoma patients were generally postmenauposal and had younger menarche age. Discussion. Advanced age, early menarche, increased endometrial thickness, hypertension and postmenapouse are risk factors for endometrial carcinoma.

Keywords


Endometrial carcinoma, risk factors

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DOI: http://dx.doi.org/10.7197/cmj.v36i1.1008002146

References


Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.

Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu Kanser Daire Başkanlığı 20042006 Yılları Türkiye Kanser İnsidansı http://kanser.gov.tr/folders/file/8iL-2006SON.pdf

Kumar V, Abbas A. Robbins and Cotran patologic basis of disease eight edition Philadelphia saunders elsevier 2010; pp: 1005-65.

Xu WH, Xiang YB, Ruan ZX, Zheng W, Cheng JR, Dai Q, Gao YT, Shu XO. Menstrual and reproductive factors and endometrial cancer risk: Results from a population-based case-control study in urban Shanghai. Int J Cancer 2004; 108: 613Sorosky JI. Endometrial cancer. Obstet Gynecol 2008; 111: 436-47.

Göksedef BP, Akbayır Ö, Çorbacıoğlu A, Güraslan H, Şencan F, Erol O, Çetin A. Comparison of preoperative endometrial biopsy grade and final pathologic diagnosis in patients with endometrioid endometrial cancer. J Turkish-German Gynecol Assoc 2012; 13: 106-10.

Aka N, Civak LÜ, Köse G, Türkay Ü, Karayel S, Aksu Ö. Endometrial Kanser: 58 Olguda Tanı ve Tedavi Deneyimi. Türk Jinekolojik Onkoloji Dergisi 2007; 10: 16-22.

Tabor A, Watt HC, Wald NJ. Endometrial thickness as a test for endometrial cancer in women with postmenopausal vaginal bleeding. Obstet Gynecol 2002; 99: 663-70.

Timmermans A, Opmeer BC, Khan KS, Bachmann LM, Epstein E, Clark TJ, Gupta JK, Bakour SH, van den Bosch T, van Doorn HC, Cameron ST, Giusa MG, Dessole S, Dijkhuizen FP, Ter Riet G, Mol BW. Endometrial thickness measurement for detecting endometrial cancer in women with postmenopausal bleeding: a systematic review and meta-analysis. Obstet Gynecol 2010; 116: 160

Sorosky, Joel I. Endometrial Cancer. Obstetrıcs & Gynecology 2012; 120: 383

Langer RD, Pierce JJ, O'Hanlan KA, Johnson SR, Espeland MA, Trabal JF, Barnabei VM, Merino MJ, Scully RE. Transvaginal Ultrasonography Compared With Endometrial Biopsy For The Detection Of Endometrial Disease. Postmenopausal Estrogen/Progestin Interventions Trial. N Engl J Med 1997; 337: 1792Gull B, Carlsson S, Karlsson B, Ylöstalo P, Milsom I, Granberg S. Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding: is it always necessary to perform an endometrial biopsy? Am J Obstet Gynecol 2000; 182: 509-15.

Smith-Bindman R, Kerlikowske K, Feldstein VA, Subak L, Scheidler J, Segal M, Brand R, Grady D. Endovaginal Ultrasound To Exclude Endometrial Cancer And Other Endometrial Abnormalities. Jama 1998; 280: 1510-7.

Granberg S, Karlsson B, Wikland M, Gull B: Uterus ve Endometriyum Hastalıklarının Transvajinal Sonografisi. In: Fleischer AC, Manning FA, Jeanty P, Romero R, (eds.) Obstetrik ve Jinekolojide Sonografi, beşinci baskı, Ulusal Tıp Kitabevi 2000; 851-68.

Berek SJ. Berek&novak’s Gynecology 14th edition, Philadelphia William&Wilkins, 2007.

Erkun E: Hormon Replasman Tedavisi ve Endometrium Kanseri. In: Ertungealp E, Seyisoğlu H, (eds.) Menopoz ve Osteoporoz, birinci baskı, Menopoz ve Osteoporoz Derneği, İstanbul, 2000; 283-6.

Chamlian DL, Taylor HB. Endometrial hyperplasia in young women. Obstet Gynecol 1970; 36: 659-66.

Parazzini F, Negri E, La Vecchia C, Benzi G, Chiaffarino F, Polatti A, Francheschi S. Role of reproductive factors on the risk of endometrial cancer. Int J Cancer 1998; 76: 784-6.

Parazzini F, La Vecchia C, Negri E, Fedele L, Balotta F. Reproductive factors and risk of endometrial cancer. Am J Obstet Gynecol 1991; 164: 522-7.

McPherson CP, Sellers TA, Potter JD, Bostick RM, Folsom AR. Reproductive factors and risk of endometrial cancer. The Iowa Women's Health Study. Am J Epidemiol 1996; 143: 1195-202.

Lİchen ML, Lund E. Childbearing and mortality from cancer of the corpus uteri. Acta Obstet Gynecol Scand 1997; 76: 373-7.

Gerber J, Sozański L, Suchocki S. The risk factors of endometrial cancer. Ginekol Pol 2001; 72(12A): 1418-22.

Noto H, Osame K, Sasazuki T, Noda M. Substantially increased risk of cancer in patients with diabetes mellitus: a systematic review and meta-analysis of epidemiologic evidence in Japan. J Diabetes Complications 2010; 24: 345-53.

Friberg E, Orsini N, Mantzoros CS, Wolk A. Diabetes mellitus and risk of endometrial cancer: a meta-analysis. Diabetologia 2007; 50: 1365-74.

Nicholas Z, Hu N, Ying J, Soisson P, Dodson M, Gaffney DK. Impact of Comorbid Conditions on Survival in Endometrial Cancer. Am J Clin Oncol 2012 Dec 13

Brinton LA, Lacey JV Jr, Devesa SS: Epidemiology of uterine corpus cancer. In Gershenson DM, McGuire WP, Gore M, Quinn MA, Thomas G. (eds): Gynecologic Cancer: Controversies in Management. New York, Churchill Livingstone, 2004; pp: 190.

Viswanathan AN1, Feskanich D, De Vivo I, Hunter DJ, Barbieri RL, Rosner B, Colditz GA, Hankinson SE. Smoking and the risk of endometrial cancer: Results from the Nurses' Health Study. Int J Cancer 2005; 114: 996-1001.




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