Management and prognosis in thymoma: experience from a single center

Yıllar Lehimcioğlu, İlknur Aytaş, Sercan Özyurt, Rahşan Habiboğlu, Ferit Çetinyokuş, Haluk Sayan, Leyla Kayaaslan, Nalan Aslan, Ferdi Aksaray, Mübeccel Tümöz
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Abstract


Abstract

Aim. This report retrospectively documents the management of in 11 patients with thymoma at Ankara Numune Education and Research Hospital Radiation Oncology Department from 1999 to 2007. Method. A total of eleven patients that admitted with the diagnosis of thymoma to own clinic between November 1999 and April 2007 were included. The medical files of the patients were retrospectively reviewed. Gender, age, subtype of thymoma, surgical procedures performed and radiotherapy doses were taken into consideration. Result. There were one patient with Type B1 thymoma, one with type B3 thymoma and nine patients with type B2. Eight patients underwent surgery, while three had biopsy alone. Overall survival rate was 71% and mean survival duration was 56 months. There was no statistically significant differences in survival rate with respect to sex, mean survival rate was 73% in males and 60% in females. Although the survival rate was higher in patients that underwent surgery than those that underwent biopsy alone, the difference was not statistically significant (75% vs 66%, respectively). Conclusion. Survival rate was increased in patients with thymoma by radiotherapy and our results are similar with literatures.

Key words: Thymoma, timus, tumor, resection

 

Özet

Amaç. Ankara Numune Eğitim ve Araştırma Hastanesi Radyasyon Onkolojisi Kliniği’nde 1999-2007 yılları arasında tedavi gören 11 timoma olgusu retrospektif olarak değerlendirildi. Yöntem. Kasım 1999 ile Nisan 2007 tarihleri arasında kliniğimize timoma tanısı ile başvuran 11 hasta çalışmaya dahil edildi. Hastaların dosyaları retrospektif olarak incelendi. Cinsiyet, yaş, timoma alt tipi, cerrahi tipi ve tedavi dozunda değerlendirmeye alındı. Bulgular. Hastalardan 1’i tip B1 timoma, 1’i tip B3 timoma, geri kalan 9 hasta ise Tip B2 timomadır. Hastalardan 8’ine cerrahi tedavi, 3’üne sadece biyopsi uygulanmıştır. Genel sağkalım %71 olarak bulundu. Ortalama sağkalım 56 aydır. Cinsiyete göre istatistiksel olarak anlam saptanmadı; erkek cinsiyette sağkalım %73, kadın cinsiyette %60’dır. Operasyon açısından sağkalım; biopsi uygulananlarda %66, opere olanlarda %75 olarak bulundu. Sonuç. Timoma tanılı hastalarda sağkalım radyoterapi ile yükselmiştir ve bulgularımız literatür ile uyumludur.

Anahtar sözcükler: Timoma, timus, tümör, rezeksiyon


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